How is mitomycin C prepared for trabeculectomy?
To prepare the MMC injection, the surgeon used a 20-ug preparation starting with MMC 0.4 mg/mL, diluting 0.1 mL of MMC (40 μg) in 0.1 mL of lidocaine (1:1, total volume of 0.2 mL). Half of that solution (0.1 mL of MMC:lidocaine [20 μg]) was used for injection. Topical anesthesia was instilled.
What is mitomycin C used for?
Its use and application in ophthalmology has been increasing in recent years because of its modulatory effects on wound healing. Current applications include pterygium surgery, glaucoma surgery, corneal refractive surgery, cicatricial eye disease, conjunctival neoplasia and allergic eye disease.
What is mitomycin used for in eye surgery?
Mitomycin C (MMC) is an antimetabolite used during the initial stages of a trabeculectomy to prevent excessive postoperative scarring and thus reduce the risk of failure.
Why antimetabolites such as mitomycin C and 5 FU are used in glaucoma surgery?
Antimetabolites are used during surgery to reduce postoperative scarring during wound healing. Two agents in common use are mitomycin C (MMC) and 5-Fluorouracil (5-FU). Objectives: To assess the effects of MMC compared to 5-FU as an antimetabolite adjunct in trabeculectomy surgery.
What are the side effects of mitomycin C?
Common side effects of Mutamycin (mitomycin) include nausea and vomiting (may be severe), stomach/abdominal pain, loss of appetite, headache, blurred vision, drowsiness, dizziness, or weakness. Temporary hair loss may occur. Normal hair growth should return after treatment with Mutamycin has ended.
How do you make mitomycin C 0.02 eye drops?
Our preparation of the mitomycin-C includes mixing the drug with a sterile water diluent to achieve a starting concentration of 0.2 mg/ml. This is then diluted further with 2% lidocaine—the same lidocaine we would use in a retrobulbar block.
How long does mitomycin C last?
Conclusions: Dissolved MMC can be stored in the refrigerator for up to 3 months without significant loss of activity. Storage at room temperature is not recommended.
Can you prevent glaucoma?
Regular, moderate exercise may help prevent glaucoma by reducing eye pressure. Talk with your doctor about an appropriate exercise program. Take prescribed eyedrops regularly. Glaucoma eyedrops can significantly reduce the risk that high eye pressure will progress to glaucoma.
How does mitomycin C work?
Mitomycin C works by interfering with the development of the genetic material in a cell, the DNA. This stops it from dividing into 2 new cells and kills it. So it destroys quickly dividing cells, such as cancer cells.
Does mitomycin affect your immune system?
Mitomycin can also weaken (suppress) your immune system, and you may get an infection more easily. Call your doctor if you have signs of infection (fever, weakness, cold or flu symptoms, skin sores, frequent or recurring illness).
How do you reconstitute mitomycin C?
Mitomycin-C should be reconstituted in sterile water at neutral pH, the drug is inactivated in an acidic solution. The drug should be stored under refrigeration to preserve its potency under these conditions, Mitomycin-C is potent for a period of two weeks [3]. The drug is available in a vial (2mg/ml and 10mg/ml).
Is mitomycin C chemotherapy?
Mitomycin is a chemotherapy drug used to treat different cancers including breast, bladder, stomach, pancreatic, anal and lung cancers.
What is the success rate of trabeculectomy with mitomycin C?
Trabeculectomy with mitomycin C remains the standard surgery for glaucoma. This surgery involves creating a door in the eye wall in order to improve fluid outflow and decrease intraocular pressure. However, success rates range from 70% to 90% depending on the criteria used and tend to decrease with time.
Can a trabeculectomy be done with ranibizumab?
Trabeculectomy With Mitomycin C Associated With Sub-conjunctival Injection of Ranibizumab. This surgery involves creating a door in the eye wall in order to improve fluid outflow and decrease intraocular pressure. However, success rates range from 70% to 90% depending on the criteria used and tend to decrease with time.
Which is better trabeculectomy or MMC for PACG?
Conclusions: Trabeculectomy with MMC effectively reduces IOP in PACG. Long-term IOP reduction is achieved for target IOP levels in the mid-teens. Presence of a crystalline lens, lack of iridotomy and higher preoperative IOP were associated with higher risks of failure.