How does familial adenomatous polyposis affect the body?
Familial adenomatous polyposis (FAP) is a rare, inherited condition caused by a defect in the adenomatous polyposis coli (APC) gene. Most people inherit the gene from a parent. But for 25 to 30 percent of people, the genetic mutation occurs spontaneously. FAP causes extra tissue (polyps) to form in your large intestine (colon) and rectum.
When do you need surgery for adenomatous polyposis?
If untreated, the polyps in the colon and rectum are likely to become cancerous when you are in your 40s. Most people with familial adenomatous polyposis eventually need surgery to remove the large intestine to prevent cancer.
Can a person with Gardner syndrome have polyps?
People who have colon polyps as well as growths outside the colon are sometimes described as having Gardner syndrome. A milder type of familial adenomatous polyposis, called autosomal recessive familial adenomatous polyposis, has also been identified.
What happens If adenomatous polyps are left untreated?
The most prominent and consistent feature is the development of multiple adenomatous polyps throughout the colon and rectum. Left untreated, there is a near 100% risk of developing colorectal cancer (CRC), with the average age of diagnosis at 40 years old.
Is there such a thing as Gardner polyposis?
People who have colon polyps as well as growths outside the colon are sometimes described as having Gardner syndrome.A milder type of familial adenomatous polyposis, called autosomal recessive familial adenomatous polyposis, has also been identified.
How is familial multiple polyposis syndrome related to genetics?
Familial multiple polyposis syndrome. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.