What does high soluble transferrin receptor mean?
The concentration of soluble transferrin receptor (sTfR) will be increased with iron deficiency. If the sTfR concentration is elevated in someone with anaemia, then it is likely that the person has iron deficiency anaemia.
How do you reduce transferrin saturation?
Transferrin saturation is decreased with iron deficiency. If the iron level and transferrin saturation are high, the TIBC, UIBC and ferritin are normal and the person has a clinical history consistent with iron overdose, then it is likely that the person has iron poisoning.
How do you raise transferrin levels?
Ways to Increase Transferrin Levels
- Avoid foods that are high in iron, such as red meat, fish, and poultry .
- Eat more foods that reduce iron absorption such as fiber and phytic acid (from whole grains) and chili [44, 45, 46].
Why is sTfR high in iron deficiency anemia?
The sTfR level is elevated in various iron deficiency states such as iron-deficient erythropoiesis, and IDA. Also, there are reports suggesting that sTfR is effective in distinguishing anemia due to chronic inflammation from IDA6,7,8).
What happens if transferrin saturation is low?
The normal range for transferrin is 204 to 360 mg/dl. If you have a higher amount, you may have iron-deficiency anemia. If you have a lower level, you may have another problem, such as liver disease and hemolytic anemia. Transferrin may also be measured using a value called total iron-binding capacity (TIBC).
What causes low transferrin levels?
Low transferrin can be due to poor production of transferrin by the liver (where it’s made) or excessive loss of transferrin through the kidneys into the urine. Many conditions including infection and malignancy can depress transferrin levels. The transferrin is abnormally high in iron deficiency anemia.
What causes low transferrin?
What happens if your transferrin saturation is low?
For example, a low transferrin saturation percentage is often seen in cases of iron deficiency, anaemia and pregnancy. If plasma transferrin levels rise then this causes a decrease in transferrin iron saturation, which together causes an increase in total iron binding capacity in states of iron deficiency.
What causes low ferritin?
Causes of low ferritin levels A lower-than-normal ferritin level can indicate that you have an iron deficiency, which can happen when you don’t consume enough iron in your daily diet. Another condition that affects iron levels is anemia, which is when you don’t have enough red blood cells for iron to attach to.
Why is TIBC decreased in anemia of chronic disease?
The total iron-binding capacity (TIBC), an indirect measurement of transferrin, is low in anemia of chronic disease because there is ample iron, but it is not easily available. TIBC tends to be increased when iron stores are diminished and decreased when they are elevated.
Are there soluble transferrin receptors for iron deficiency anemia?
Soluble transferrin receptor was significantly increased in children with iron deficiency anemia (median: 1.63 μg/ml) compared to non-anemic children (median: 1.02 μg/ml).
What to do if soluble transferrin receptor is low?
Usually the soluble transferrin receptor values are also low. Iron should be given as Fe2+ (bivalent iron) together with vitamin C to increase absorption of iron from the gut. If ferritin levels do not rise and the symptoms are bothersome, intravenous iron might be considered.
Which is higher soluble transferrin receptor or log ferritin index?
Soluble transferrin receptor/log ferritin index was significantly higher in iron deficiency anemia (median: 1.76) than in anemia of chronic disease (median: 0.55), anemia of chronic disease with iron deficiency (median: 0.68) or patients without anemia (median: 0.72).
When does soluble transferrin become a marker of erythropoiesis?
Soluble TfR is therefore only a marker of erythropoiesis when iron stores are adequate and available and additionally becomes a marker of iron status only when tissue iron deficiency (with or without adequate iron stores) occurs. Cellular iron uptake is mediated by a specific receptor for transferrin.