Categories :

Is TMP SMX bacteriostatic?

Is TMP SMX bacteriostatic?

Tetrahydrofolate is crucial in the synthesis of purines, thymidine, and methionine which are needed for the production of DNA and proteins during bacterial replication. Thus the net effect of each of these drugs is a bacteriostatic halt in replication. When combined, TMP and SMX are bactericidal.

Is septrin bactericidal?

This antibacterial also possesses antimalarial properties. When used alone, trimethoprim is bacteriostatic, but it is bactericidal when combined with sulfonamides.

Why is cotrimoxazole bactericidal?

In nutrient broth the components of cotrimoxazole did not produce bacteriostatic synergy against most sulphonamide-resistant and a significant proportion of sulphonamide-sensitive strains. Any bactericidal action appeared to be due to the trimethoprim component.

Are sulfonamides bactericidal or bacteriostatic?

Sulfonamides are synthetic bacteriostatic antibiotics that competitively inhibit conversion of p-aminobenzoic acid to dihydropteroate, which bacteria need for folate synthesis and ultimately purine and DNA synthesis.

What does TMP-SMX stand for?

Trimethoprim-sulfamethoxazole (TMP-SMX) is the drug of choice for the treatment of uncomplicated community-acquired urinary tract infections (UTIs) in areas where the prevalence of TMP-SMX—resistant pathogens is µ10% [1].

Are Bactrim and Septra the same?

Are Bactrim and Septra the Same Thing? Bactrim (sulfamethoxazole and trimethoprim) is a combination of two antibiotics and Septra (trimethoprim and sulfamethoxazole) is a quinolone antibiotic. Both drugs are used to treat bacterial infections such as urinary tract infections, bronchitis and other lung infections.

What is the other name for cotrimoxazole?

Septrin is a brand name for a combination of antibiotics called cotrimoxazole. The same medication is available from other manufacturers with many different brand names, including Bactrim. Cotrimoxazole has two components: sulfamethoxazole and trimethoprim. Cotrimoxazole is a broad spectrum antibiotic.

What is another name for co-trimoxazole?

Trimethoprim/sulfamethoxazole (TMP/SMX), also known as co-trimoxazole among other names, is a combination antibiotic used to treat a variety of bacterial infections.

Who should not take sulfonamides?

Who should not take ?

  • porphyria.
  • anemia from inadequate folic acid.
  • a blood disorder.
  • liver problems.
  • decreased kidney function.
  • anemia from pyruvate kinase and G6PD deficiencies.
  • third trimester of pregnancy.