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What is the difference between drug selectivity and drug specificity?

What is the difference between drug selectivity and drug specificity?

For example a selective drug would have the ability to discriminate between, and so affect only one cell population, and thereby produce an event. Specificity, a term most often confused with selectivity, will be used to describe the capacity of a drug to cause a particular action in a population.

What is selectivity in pharmacology?

Selectivity is the degree to which a drug acts on a given site relative to other sites. Relatively nonselective drugs affect many different tissues or organs.

What is drug specificity in pharmacology?

drugs. Specificity is the measure of a receptors ability to respond to a single ligand (1-5). Low specificity generally results in physiological responses not targeted or intended by. the drug and side effects provide a good example. Indeed, it is not uncommon for a drug.

What are the 4 categories of drug actions?

There are four types of ligand that act by binding to a cell surface receptor, agonists, antagonists, partial agonists, and inverse agonists (Figure 1).

What are the three types of drug interactions?

Drug interactions can be categorised into 3 groups:

  • Interactions of drugs with other drugs (drug-drug interactions),
  • Drugs with food (drug-food interactions)
  • Drug with disease condition (drug-disease interactions).

How is drug selectivity determined?

Selectivity is defined as the ratio of the affinity of the compound towards the off-target protein relative to the target protein (Kd ratio = Kd,off target/Kd,target). The larger the Kd ratio, the better the selectivity.

What do you mean by selectivity?

the state or quality of being selective. Electricity. the property of a circuit, instrument, or the like, by virtue of which it can distinguish oscillations of a particular frequency. Radio. the ability of a receiving set to receive any one of a band of frequencies or waves to the exclusion of others.

What is the entry of drugs into the plasma?

The extent of drug distribution into tissues depends on the degree of plasma protein and tissue binding. In the bloodstream, drugs are transported partly in solution as free (unbound) drug and partly reversibly bound to blood components (eg, plasma proteins, blood cells).

What is meant by receptor specificity?

Binding of an extracellular signal to its receptor involves the same type of interactions as those between an enzyme and its substrate. Receptor specificity depends on the binding affinity between the ligand and the binding site on the receptor.

What are the two types of pharmacology?

The two main areas of pharmacology are pharmacodynamics and pharmacokinetics. Pharmacodynamics studies the effects of a drug on biological systems, and pharmacokinetics studies the effects of biological systems on a drug.

Which is the most common type of drug interaction?

pharmacokinetic – defined as an alteration in the absorption, distribution, metabolism or excretion of one drug by another. This is the most common type of drug interaction. pharmacodynamic – where the drug affects the action or effect of the other drug.

What are the most common drug interactions?

Which are Some Common Drug-Drug interactions?

  • Digoxin and Amiodarone.
  • Digoxin and Verapamil.
  • Theophylline and Quinolones.
  • Warfarin and Macrolides.
  • Warfarin and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
  • Warfarin and Phenytoin.
  • Warfarin and Quinolones.
  • Warfarin and Sulfa Drugs.

What is the difference between selectivity and specificity?

Specificity is defined as “the ability to assess unequivocally the analyte in the presence of components which might be expected to be present.” The terms selectivity and specificity are often used interchangeably.

When to use selectivity in pharmacodynamics clinical practice?

For instance, ‘cardioselective’ β-­‐adrenoceptor blocking drugs have anti-­‐anginal effects on the heart (β1) but may cause bronchospasm in the lung (β2) and are absolutely contraindicated for asthmatic patients. Selectivity is useful in clinical practice only when the ratio of the impact of the drug at the two receptor sites is 100 or more.

What’s the difference between selective and specific methods?

Inconsistent with ICH, the term specific generally refers to a method responding to a single analyte only, while the term selective refers to a method which provides responses for a number of chemical entities that may or may not be distinguished from each other.

What does it mean when drug selectivity is lower?

When selectivity is lower, it is difficult to predict drug doses that will exploit the difference in subtype activity. The term selectivity is use to describe the ability of a drug to affect a particular gene, protein, signaling pathway, etc. in preference to others.