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What does the Slug gene do?

What does the Slug gene do?

Zinc finger protein SNAI2 is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes the differentiation and migration of certain cells and has roles in initiating gastrulation.

What is slug protein?

SLUG protein function Involved in the generation and migration of neural crest cells. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

Is Slug a transcription factor?

As a transcription factor, SLUG may mediate cell survival and drug resistance in cancer cells by regulation set of genes functioning in various signalling pathways.

What is Twist gene?

TWIST1 (Twist Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with TWIST1 include Saethre-Chotzen Syndrome and Craniosynostosis 1. Among its related pathways are Proteoglycans in cancer and HIF-2-alpha transcription factor network.

Are slugs an animal?

Slugs and snails belong to the Phylum Mollusca and are more closely related to octopi than insects. Mollusks are a large and diverse group of animals of worldwide distribution. The slugs and snails are much like some insects in their biology.

What are EMT markers?

Cell-surface markers of EMT. A change in expression of E-cadherin is the prototypical epithelial cell marker of EMT. E-cadherin is expressed in epithelial cells, and its expression is decreased during EMT in embryonic development, tissue fibrosis, and cancer (65).

What is EMT biology?

An epithelial-mesenchymal transition (EMT) is a biologic process that allows a polarized epithelial cell, which normally interacts with basement membrane via its basal surface, to undergo multiple biochemical changes that enable it to assume a mesenchymal cell phenotype, which includes enhanced migratory capacity.

What causes Saethre Chotzen syndrome?

Saethre-Chotzen syndrome is caused by a change in a gene (TWIST1) that affects how a baby’s head and limbs develop before birth. Our Craniofacial Genetics Clinic helps identify conditions caused by changes in genes. Our geneticists and genetic counselors can advise you about the pros and cons of genetic testing.

What do slugs hate?

Slugs and snails are also known to have a dislike for plants with a strong fragrance, and lavender definitely gets up their collective nose. Whilst many humans adore the rich smell of lavender in their garden and around their home, garden-dwelling molluscs will be turned off.

Do slugs feel pain?

“Because a slug responds to a stimulus that we think is painful doesn’t mean it is experiencing pain,” says Chudler. “A person who is anaesthetised, ready for surgery, may still pull his hand away when he’s pinched. He’s just pulling it away because of the flexion reflex – and that comes from the spinal cord.

What triggers EMT?

EMT has been shown to be induced by androgen deprivation therapy in metastatic prostate cancer. Activation of EMT programs via inhibition of the androgen axis provides a mechanism by which tumor cells can adapt to promote disease recurrence and progression.

What is cytokeratin a marker for?

Measuring the amount of specific cytokeratins in the blood may help to plan cancer treatment or find out how well treatment is working or if cancer has come back. A cytokeratin is a type of tumor marker. Also called keratin.

What is the function of the SNAI2 gene?

Zinc finger protein SNAI2 is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes the differentiation and migration of certain cells and has roles in initiating gastrulation. This gene encodes a member of the Snail superfamily of C2H2-type zinc finger transcription factors.

What is the role of stromal SNAI2 in breast cancer?

Stromal SNAI2 Is Required for ERBB2 Breast Cancer Progression. Fucoidan increased the sensitivity to gefitinib in lung cancer cells correlates with reduction of TGFbeta-mediated Slug expression. Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes.

What can chemical modification of siRNA be used for?

Chemical modification of siRNA is employed to reduce in the activation of the innate immune response for gene function and therapeutic applications. One promising method of reducing the nonspecific effects is to convert the siRNA into a microRNA.

What happens when siRNA is transfected with a Dicer protein?

Dicer protein colored by protein domain. Gene knockdown by transfection of exogenous siRNA is often unsatisfactory because the effect is only transient, especially in rapidly dividing cells. This may be overcome by creating an expression vector for the siRNA. The siRNA sequence is modified to introduce a short loop between the two strands.